Author details Department of Health Education and Promotion, School of Health, Zanjan University of Medical Sciences, Parvin Etesami Street, P.O. Box: 451578-6349, Zanjan, Iran. Department of Health Education and Promotion, School of Health, Tehran University of Medical Sciences, P.O. Box 15875-6951, Tehran, Iran. Mental Health Research Group, Health Metrics Research Center, Institute for Healt...

parvin etesami is a poet who artistically used persian poetry in order to criticize the status quo of the society and express its deficiencies. her divan (collection of poems), which is her only heritage for us, is teeming with debates, allegories, sarcasms with social themes. this article deals with sociological investigation of the social and class discrimination from her point of view. in ad...

Translators always seek to find the best equivalents for each word, sentence or phrase in the target language (TL) in order to have the most accurate and meaningful translation of the text. Generally, a translator’s main concern is whether to prefer the form over the content or vice versa. In translation studies, literal translation prioritizes the form while free translation concentrates on th...

Parvin is a putative F-actin binding protein important for integrin-mediated cell adhesion. Here we used overexpression of Drosophila Parvin to uncover its functions in different tissues in vivo. Parvin overexpression caused major defects reminiscent of metastatic cancer cells in developing epithelia, including apoptosis, alterations in cell shape, basal extrusion and invasion. These defects we...

Parvin-beta is a focal adhesion protein downregulated in human breast cancer cells. Loss of Parvin-beta contributes to increased integrin-linked kinase activity, cell-matrix adhesion, and invasion through the extracellular matrix in vitro. The effect of ectopic Parvin-beta expression on the transcriptional profile of MDA-MB-231 breast cancer cells, which normally do not express Parvin-beta, was...

Integrin-linked kinase (ILK), PINCH and parvin constitute the tripartite IPP complex that maintains the integrin-actin link at embryonic muscle attachment sites (MASs) in Drosophila. Here we showed that parvin null mutants in Drosophila exhibit defects in muscle adhesion, similar to ILK and PINCH mutants. Furthermore, the identical muscle phenotype of the triple mutant, which for the first time...

Leukocyte extravasation is an important step of inflammation, in which integrins have been demonstrated to play an essential role by mediating the interaction of leukocytes with the vascular endothelium and the subendothelial extracellular matrix. Previously, we identified an integrin-linked kinase (ILK)-binding protein affixin (beta-parvin), which links initial integrin signals to rapid actin ...

Visualization and quantification of the dynamics of protein-protein interactions in living cells can be used to explore the macromolecular events involved in signal transduction processes. In this study, functional molecular imaging using a luciferase-based complementation method demonstrated how the integrin-linked kinase (ILK)-mediated protein complex controls downstream signals. The lucifera...

as the form and appearance of a literature work inevitably affect thestructure and shape ofthatwork, theyplay animportant role in its permanence.in this study, factors and elementsaffecting the cohesion, coherence, form and structure of allegories and debates in parvin'scollection were analyzed using a systematic method. the results of the study can becategorizedin four groups. first, in p...

The adaptor protein paxillin contains five conserved leucine-rich (LD) motifs that interact with a variety of focal adhesion proteins, such as alpha-parvin. Here, we report the first crystal structure of the C-terminal calponin homology domain (CH(C)) of alpha-parvin at 1.05 A resolution and show that it is able to bind all the LD motifs, with some selectivity for LD1, LD2, and LD4. Cocrystal s...